Immortalized megakaryocytes, imMKCL imaged with Zeiss LSM 900 in BMB. ER-endosomes (EGFP-KDEL) and in red early endosomes (SNX17-mCherry). Video for the same is shown below. Image Credit: Andrea Ambrosio.

Comet tail motility in cell expressing lifeact. Lamin A/C deficiency enables increased myosin-II bipolar filament ensembles that promote divergent actomyosin network anomalies through self-organization. Imaged with Olympus IX83 (3I) spinning disk confocal in BMB. Image credit: Wiggan O, DeLuca JG, Stasevich TJ, Bamburg JR. Lamin A/C deficiency enables increased myosin-II bipolar filament ensembles that promote divergent actomyosin network anomalies through self-organization. Mol Biol Cell. 2020 Oct 1;31(21):2363-2378. doi: 10.1091/mbc.E20-01-0017-T. Epub 2020 Aug 20. PMID: 32816614; PMCID: PMC7851964.

Hypercontraction of nucleus in dividing cell deficient in ADF/cofilin. Chromatin being pulled between cells due to membrane-bound actin filaments anchoring to the nucleus. Image credit: Wiggan O, Schroder B, Krapf D, Bamburg JR, DeLuca JG. Cofilin Regulates Nuclear Architecture through a Myosin-II Dependent Mechanotransduction Module. Sci Rep. 2017 Jan 19;7:40953. doi: 10.1038/srep40953. PMID: 28102353; PMCID: PMC5244421.